QuarkXPress 7 has an amazing ability to render your layout in whatever color space you like.

The Grayscale option (View> Proof Output> Grayscale) is particularly handy for previewing how your entire layout will print in grayscale.

The other built-in profiles include RGB, CMYK, CMYK and Spot, and more.

You can create your own, or import profiles provided by your output provider, by choosing Edit> Color Setups… Output…
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This post was written by:
Jay Nelson - who has written 798 posts on Planet Quark.
Jay Nelson is the editorial director of PlanetQuark.com, and the editor and publisher of Design Tools Monthly. He’s also the author of the QuarkXPress 8 and QuarkXPress 7 training titles at Lynda.com, as well as the training videos Quark includes in the box with QuarkXPress 7 . In addition, Jay has a monthly Fonts column in Macworld, writes for several other publications and speaks at industry events.
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[...] I realize that this isn’t exactly a QuarkXPress topic, but it’s certainly a topic that every QuarkXPress user wrestles with: accurate color. I found that having accurate on-screen color became much more interesting when QuarkXPress 7 added the ability to display any document in any profiled color space (RGB, CMYK, CMYK+spot, press profiles, grayscale, etc.). With a calibrated display, you can actually trust the colors you’re seeing in XPress. (Note previous story “Preview in Grayscale, CMYK, and More.”) [...]